Breast cancer cells cultured in a 3D ECM-based model demonstrated altered sensitivity to doxorubicin, when compared to those grown in corresponding two-dimensional (2D) monolayer culture conditions. Investigations into the factors triggering the observed doxorubicin resistance revealed that cell-to-ECM interactions played a pivotal role. This finding correlated with the up-regulation of pro-survival proteins in 3D ECM-containing cell culture conditions following exposure to doxorubicin. Inhibition of integrin signalling in combination with doxorubicin significantly reduced breast cancer cell viability.
#Breast_Cancer2018 are delightedly invite all the #Experts to #Explore your #research in #Breast_Cancer 2018 Conference on #October 15-16,2018 @Rome, Italy
be a #Speaker #Share your #Research with our #Grand Event
#Abstract_Submission and #Registration has been Officially opened now..!!
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